ALOXE3

Arachidonate lipoxygenase 3
Identifiers
Symbols	ALOXE3 ; ARCI3; E-LOX; eLOX-3; eLOX3
External IDs	OMIM: 607206 MGI: 1345140 HomoloGene: 8013 GeneCards: ALOXE3 Gene
EC number	4.2.1.152, 5.4.4.7
Gene ontology Molecular function • iron ion binding • protein binding • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen • lyase activity • hepoxilin A3 synthase activity Cellular component • cytoplasm Biological process • sphingolipid metabolic process • sensory perception of pain • arachidonic acid metabolic process • lipoxygenase pathway • peroxisome proliferator activated receptor signaling pathway • linoleic acid metabolic process • fat cell differentiation • ceramide biosynthetic process • hepoxilin biosynthetic process • oxidation-reduction process • establishment of skin barrier Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE ALOXE3 207708 at tn.png
File:PBB GE ALOXE3 222383 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	59344	23801
Ensembl	ENSG00000179148	ENSMUSG00000020892
UniProt	Q9BYJ1	Q9WV07
RefSeq (mRNA)	NM_001165960	NM_011786
RefSeq (protein)	NP_001159432	NP_035916
Location (UCSC)	Chr 17: 8.1 – 8.12 Mb	Chr 11: 69.13 – 69.15 Mb
PubMed search	[1]	[2]

Epidermis-type lipoxygenase 3 is an enzyme that in humans is encoded by the ALOXE3 gene.

The leukotrienes constitute a group of arachidonic acid-derived compounds with biologic activities suggesting important roles in inflammation and immediate hypersensitivity. These compounds are catabolized, in part, by lipoxygenases. Epidermis-type lipoxygenases, a distinct subclass within the multigene family of mammalian lipoxygenases, are novel isoenzymes isolated from human and mouse skin including human ALOX15B (MIM 603697), human and mouse ALOX12B (MIM 603741), mouse 8S-LOX, and mouse e-LOX-3.[supplied by OMIM]