File:Paracetamol metabolism.svg
From Infogalactic: the planetary knowledge core
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Summary
Simplified schematic of the key pathways of <a href="https://en.wikipedia.org/wiki/paracetamol" class="extiw" title="w:paracetamol">paracetamol</a> <a href="https://en.wikipedia.org/wiki/drug_metabolism" class="extiw" title="w:drug metabolism">metabolism</a> in the human body. The first step in conversion of paracetamol to NAPQI has been omitted for clarity.
Set in <a href="https://en.wikipedia.org/wiki/Myriad_(typeface)" class="extiw" title="w:Myriad (typeface)">Myriad Pro</a>.
- Legend
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Pathways to non-toxic metabolites
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Pathway to toxic metabolites (<a href="https://en.wikipedia.org/wiki/cytochrome_P450" class="extiw" title="w:cytochrome P450">CYP</a>-mediated)
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Detoxification pathway
- Abbreviations
- GlcA, <a href="https://en.wikipedia.org/wiki/glucuronic_acid" class="extiw" title="w:glucuronic acid">glucuronic acid</a>; GSH, <a href="https://en.wikipedia.org/wiki/glutathione" class="extiw" title="w:glutathione">glutathione</a>; NAPQI, <a href="https://en.wikipedia.org/wiki/NAPQI" class="extiw" title="w:NAPQI">N-acetyl-p-benzoquinone imine</a>.
Licensing
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File history
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 17:49, 7 January 2017 | | 385 × 385 (185 KB) | 127.0.0.1 (talk) | Simplified schematic of the key pathways of <a href="https://en.wikipedia.org/wiki/paracetamol" class="extiw" title="w:paracetamol">paracetamol</a> <a href="https://en.wikipedia.org/wiki/drug_metabolism" class="extiw" title="w:drug metabolism">metabolism</a> in the human body. The first step in conversion of paracetamol to NAPQI has been omitted for clarity.<br>Set in <a href="https://en.wikipedia.org/wiki/Myriad_(typeface)" class="extiw" title="w:Myriad (typeface)">Myriad Pro</a>. <dl> <dd><b>Legend</b></dd> <dd><div style="direction:ltr;"> <span style="width: 2.8em; display: inline-block; text-align: center;"><span style="width: 2.4em; display: inline-block; text-align: center; border: 1px solid #808080; background-color: #0066FF;"> </span></span> Pathways to non-toxic metabolites</div></dd> <dd><div style="direction:ltr;"> <span style="width: 2.8em; display: inline-block; text-align: center;"><span style="width: 2.4em; display: inline-block; text-align: center; border: 1px solid #808080; background-color: red;"> </span></span> Pathway to toxic metabolites (<a href="https://en.wikipedia.org/wiki/cytochrome_P450" class="extiw" title="w:cytochrome P450">CYP</a>-mediated)</div></dd> <dd><div style="direction:ltr;"> <span style="width: 2.8em; display: inline-block; text-align: center;"><span style="width: 2.4em; display: inline-block; text-align: center; border: 1px solid #808080; background-color: #6600FF;"> </span></span> Detoxification pathway</div></dd> <dd><b>Abbreviations</b></dd> <dd>GlcA, <a href="https://en.wikipedia.org/wiki/glucuronic_acid" class="extiw" title="w:glucuronic acid">glucuronic acid</a>; GSH, <a href="https://en.wikipedia.org/wiki/glutathione" class="extiw" title="w:glutathione">glutathione</a>; NAPQI, <a href="https://en.wikipedia.org/wiki/NAPQI" class="extiw" title="w:NAPQI"><i>N</i>-acetyl-<i>p</i>-benzoquinone imine</a>.</dd> </dl> |
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