Pseudomonas exotoxin

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The Pseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa.[1]

It inhibits elongation factor-2.[2] It does so by ADP-ribosylation of EF2. This then causes the elongation of polypeptides to cease.(The mechanism of the toxin is similar to that of Diphtheria toxin.)

It has been investigated as a treatment for hepatitis B[3] and cancer.[4]

References

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