Phenyl salicylate

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Phenyl salicylate[1]
Skeletal formula
Ball-and-stick model
Names
IUPAC name
Phenyl 2-hydroxybenzoate
Other names
Salol
Identifiers
118-55-8 YesY
ChEBI CHEBI:34918 N
ChEMBL ChEMBL1339216 N
ChemSpider 8058 N
EC Number 204-259-2
Jmol 3D model Interactive image
KEGG C14163 N
MeSH C026041
PubChem 8361
  • InChI=1S/C13H10O3/c14-12-9-5-4-8-11(12)13(15)16-10-6-2-1-3-7-10/h1-9,14H N
    Key: ZQBAKBUEJOMQEX-UHFFFAOYSA-N N
  • InChI=1/C13H10O3/c14-12-9-5-4-8-11(12)13(15)16-10-6-2-1-3-7-10/h1-9,14H
    Key: ZQBAKBUEJOMQEX-UHFFFAOYAI
  • O=C(Oc2ccccc2)c1c(O)cccc1
Properties
C13H10O3
Molar mass 214.22 g/mol
Appearance White solid
Density 1.25 g/cm3
Melting point 41.5 °C (106.7 °F; 314.6 K)
Boiling point 173 °C (343 °F; 446 K) at 12 mmHg
1 g/6670 mL
1.615[2]
Pharmacology
ATC code G04BX12
Vapor pressure {{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Phenyl salicylate, or salol, is a chemical substance, introduced in 1886 by Marceli Nencki of Basel. It can be created by heating salicylic acid with phenol. Once used in sunscreens, phenyl salicylate is now used in the manufacture of some polymers, lacquers, adhesives, waxes and polishes.[1] It is also used frequently in school laboratory demonstrations on how cooling rates affect crystal size in igneous rocks.

Salol reaction

In the salol reaction, phenyl salicylate reacts with o-toluidine in 1,2,4-trichlorobenzene at elevated temperatures to the corresponding amide o-Salicylotoluide.[3] Salicylamides are one type of drug.

Medical

It has been used as an antiseptic[4] based on the antibacterial activity upon hydrolysis in the small intestine.[citation needed]

It acts as a mild analgesic.[5]

References

  1. 1.0 1.1 Merck Index, 11th Edition, 7282.
  2. ChemBK Chemical Database http://www.chembk.com/en/chem/Phenyl%20salicylate
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