4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
| 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.17.7.1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, a 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (HMB-PP synthase, IspG, EC 1.17.7.1) is an enzyme that catalyzes the chemical reaction
- 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + protein-dithiol
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + protein-disulfide
The substrate of this enzyme is 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEcPP) and the product is (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate (HMB-PP). Electrons are donated by two reduced ferredoxin proteins per reaction.
This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 groups with a disulfide as acceptor. The systematic name of this enzyme class is (E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating). This enzyme participates in the MEP pathway (non-mevalonate pathway) of Isoprenoid precursor biosynthesis.
References
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