8-Phenyltheophylline

8-Phenyltheophylline

Systematic (IUPAC) name
8-phenyl-1,3-dimethyl-7H-purine-2,6-dione
Identifiers
CAS Number	961-45-5 N
PubChem	CID: 1922
ChemSpider	1846 Y
ChEMBL	CHEMBL62350 Y
Chemical data
Formula	C13H12N4O2
Molecular mass	256.259 g/mol
SMILES c3ccccc3-c(nc12)nc2n(C)c(=O)n(C)c1=O
InChI InChI=1S/C13H12N4O2/c1-16-11-9(12(18)17(2)13(16)19)14-10(15-11)8-6-4-3-5-7-8/h3-7H,1-2H3,(H,14,15) Y Key:PJFMAVHETLRJHJ-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

8-Phenyltheophylline (8-Phenyl-1,3-dimethylxanthine, 8-PT) is a drug derived from the xanthine family which acts as a potent and selective antagonist for the adenosine receptors A₁ and A_2A, but unlike other xanthine derivatives has virtually no activity as a phosphodiesterase inhibitor. It has stimulant effects in animals with similar potency to caffeine. Coincidentally 8-phenyltheophylline has also been found to be a potent and selective inhibitor of the liver enzyme CYP1A2 which makes it likely to cause interactions with other drugs which are normally metabolised by CYP1A2.

See also

• 8-Chlorotheophylline
• 8-Cyclopentyltheophylline
• DPCPX
• DMPX
• Xanthine