A-412,997

A-412,997

Systematic (IUPAC) name
N-(3-methylphenyl)-2-(4-pyridin-2-ylpiperidin-1-yl)acetamide
Identifiers
CAS Number	630116-49-3 1347744-96-0 (di‑hydrochloride)
PubChem	CID: 10425450
IUPHAR/BPS	3301
ChemSpider	8600878 Y
ChEMBL	CHEMBL375596 Y
Chemical data
Formula	C19H23N3O
Molecular mass	309.405 g/mol
SMILES CC1=CC(NC(CN2CCC(C3=CC=CC=N3)CC2)=O)=CC=C1
InChI InChI=1S/C19H23N3O/c1-15-5-4-6-17(13-15)21-19(23)14-22-11-8-16(9-12-22)18-7-2-3-10-20-18/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,21,23) Y Key:JFCDMGGMCUKHST-UHFFFAOYSA-N Y
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A-412,997 is a drug which acts as a dopamine agonist that is used in scientific research. It is the first drug developed that is a highly selective agonist for the D₄ subtype, with significantly improved selectivity over older D₄-preferring compounds such as PD-168,077 and CP-226,269. In animal tests it improved cognitive performance in rats to a similar extent as methylphenidate, but without producing place preference or other signs of abuse liability. Also unlike other dopamine agonists, selective D₄ agonists do not cause side effects such as sedation and nausea, and so might have advantages over older dopamine agonist drugs.