ATG16L1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Autophagy-related protein 16-1 is a protein that in humans is encoded by the ATG16L1 gene.[1]
Function
Autophagy is the major intracellular degradation system delivering cytoplasmic components to lysosomes, and it accounts for degradation of most long-lived proteins and some organelles. Cytoplasmic constituents, including organelles, are sequestered into double-membraned autophagosomes, which subsequently fuse with lysosomes. ATG16L1 is a component of a large protein complex essential for autophagy.[2][3]
Clinical significance
Mutations in the ATG16L1 gene may be linked to Crohn's disease.[4][5][6]
References
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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