Anti-IL-6
Anti-interleukin-6 agents are a class of therapeutics. Interleukin 6 is a cytokine relevant to many inflammatory diseases and many cancers.[1] Hence, anti-IL6 agents have been sought.[2][3][4][5][6] In rheumatoid arthritis they can help patients unresponsive to TNF.[7]
The first approved medication in this class, tocilizumab (Actemra), is an antibody directed against the IL6-receptor.[8] The second, siltuximab (Sylvant), is directed against IL-6 itself.[1][9]
Several agents are in clinical trials: sarilumab,[10] olokizumab (CDP6038)[11][12] elsilimomab, BMS-945429(ALD518), sirukumab (CNTO 136), and CPSI-2364 an apparent macrophage-specific inhibitor of the p38 mitogen-activated protein kinase pathway.[13] ALX-0061.[7]:Table1
eg. for rheumatoid arthritis : clazakizumab, olokizumab, sarilumab and sirukumab have all reported encouraging phase 2 results.[7] Sirukumab is in multiple phase 3 trials.[7]:Table1
Agents in pre-clinical development include ARGX-109,[14][15] FE301,[1] FM101[16]
Exercise induced IL-6 may be beneficial
New research has found IL-6 to be an anti-inflammatory cytokine with multiple beneficial effects when released by contracting muscle as a myokine. IL-6 had previously been classified as a proinflammatory cytokine. Therefore, it was first thought that the exercise-induced IL-6 response was related to muscle damage.[17] However, it has become evident that eccentric exercises are not associated with a larger increase in plasma IL-6 than exercise involving concentric “nondamaging” muscle contractions. This finding demonstrates that muscle damage is not required to provoke an increase in plasma IL-6 during exercise. In fact, eccentric exercise may result in a delayed peak and a much slower decrease of plasma IL-6 during recovery.[18] Anti-IL-6 therapies should therefore take into consideration the (beneficial) anti-inflammatory effects of myokines generally, including the now-established multiple benefits of muscle-derived Interleukin 6.[18]
Food and diet
It has been reported that lunasin, a soy peptide, reduces inflammation by reducing interleukin 6 and may help in leukemia[vague].[19]
Luteolin reduces IL-6 production in some neurons.[20]
References
- ↑ 1.0 1.1 1.2 Lua error in package.lua at line 80: module 'strict' not found.
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- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 7.0 7.1 7.2 7.3 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/125496s000lbl.pdf
- ↑ http://www.clinicaltrials.gov/ct2/results?term=sarilumab
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ http://www.pharmatimes.com/article/12-09-28/UCB_s_RA_drug_does_not_overly_impress_in_Phase_II.aspx
- ↑ PMID: 23598944
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ http://www.prnewswire.com/news-releases/ruiyi-formerly-anaphore-and-argen-x-announce-exclusive-worldwide-license-agreement-for-argx-109-a-novel-anti-il-6-antibody-172634271.html
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Bruunsgaard H, Galbo H, Halkjaer-Kristensen J, Johansen TL, MacLean DA, Pedersen BK. Exercise-induced increase in interleukin-6 is related to muscle damage. J Physiol Lond 499: 833-841, 1997.
- ↑ 18.0 18.1 Muscle as a secretory organ. Pedersen BK. American Physiological Society. Compr Physiol 3:1337-1362, 2013. http://www.inflammation-metabolism.dk/index.php?pageid=21&pmid=23897689
- ↑ http://www.foodconsumer.org/newsite/Nutrition/Supplements/soy_protein_helps_fight_cancer_and_inflammation_021220090906.html
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
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