Bococizumab

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Bococizumab
Monoclonal antibody
Type Whole antibody
Source Humanized (from mouse)
Target Proprotein convertase subtilisin/kexin type 9 (PCSK9)
Clinical data
Legal status
  • Investigational
Routes of
administration		 Subcutaneous injection
Identifiers
CAS Number 1407495-02-6
ATC code none
PubChem SID: 194168554
IUPHAR/BPS 7730
ChEMBL CHEMBL3137349
Chemical data
Formula C6414H9918N1722O2012S54
Molecular mass 145.1 kg/mol

Bococizumab[1] (RN316)[2] is a drug in development by Pfizer targeting PCSK9 to reduce LDL cholesterol.[3]

Description

Bococizumab is a monoclonal antibody that inhibits PCSK9, a protein that interferes with the removal of LDL. LDL levels are a major risk factor for cardiovascular disease.[4]

Clinical trials

A phase 2b study of statin patients was presented at the 2014 American College of Cardiology. Monthly or bimonthly injections resulted in significantly reduced LDL-C at week 12.

The Phase 3 SPIRE trials plan to enroll 17,000 patients to measure cardiovascular risk. High risk and statin intolerant subjects will be included.

References

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