Cicletanine

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Cicletanine
File:Cycletanide.png
Systematic (IUPAC) name
3-(4-Chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol
Clinical data
AHFS/Drugs.com International Drug Names
Routes of
administration		 Oral
Pharmacokinetic data
Protein binding 97.3%
Biological half-life 7.9 h
Identifiers
CAS Number 89943-82-8
ATC code C03BX03 (WHO)
PubChem CID: 54910
ChemSpider 49583 YesY
UNII CHG7QC509W YesY
KEGG D03487 YesY
ChEMBL CHEMBL191886 YesY
Chemical data
Formula C14H12ClNO2
Molecular mass 261.703 g/mol
  • Clc1ccc(cc1)C3OCc2c3cnc(c2O)C
  • InChI=1S/C14H12ClNO2/c1-8-13(17)12-7-18-14(11(12)6-16-8)9-2-4-10(15)5-3-9/h2-6,14,17H,7H2,1H3 YesY
  • Key:CVKNDPRBJVBDSS-UHFFFAOYSA-N YesY
  (verify)

Cicletanine is a furopyridine low-ceiling diuretic drug, usually used in the treatment of hypertension.[1] The drug is manufactured by Ipsen and marketed by Recordati (in France) under the trade name Tenstaten.

It appears to be more potent in salt-sensitive hypertension.[2]

Mechanism

It can inhibit protein kinase C.[3]

References

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External links


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  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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