Clobetasone

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Clobetasone
Clobetasone.png
Systematic (IUPAC) name
(1R,2S,10S,11S,13S,14R,15S)-14-(2-chloroacetyl)-1-fluoro-14-hydroxy-2,13,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-diene-5,17-dione
Clinical data
Trade names Eumovate
AHFS/Drugs.com Micromedex Detailed Consumer Information
Routes of
administration		 topical
Identifiers
CAS Number 54063-32-0 YesY
ATC code D07AB01 (WHO) S01BA09
PubChem CID: 71387
ChemSpider 64482 YesY
UNII LT69WY1J6D YesY
KEGG D07717 YesY
Synonyms (8S,9R,10S,13S,14S,16S,17R)-17-(2-Chloroacetyl)-9-fluoro-17-hydroxy-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthrene-3,11-dione
Chemical data
Formula C22H26ClFO4
Molecular mass 408.891 g/mol
  • ClCC(=O)[C@@]2(O)[C@@H](C)C[C@H]1[C@H]4[C@](F)(C(=O)C[C@@]12C)[C@@]/3(/C(=C\C(=O)\C=C\3)CC4)C
  • InChI=1S/C22H26ClFO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-16,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,19-,20-,21-,22-/m0/s1 YesY
  • Key:XXIFVOHLGBURIG-OZCCCYNHSA-N YesY
  (verify)

Clobetasone (INN[1]) is a corticosteroid used in dermatology, for treating such skin inflammation as seen in eczema, psoriasis and other forms of dermatitis, and ophthalmology. Topical clobetasone butyrate has shown minimal suppression of the Hypothalamic-pituitary-adrenal axis.[2]

It is available as clobetasone butyrate under the brand names Eumosone or Eumovate[3] both manufactured by GlaxoSmithKline.

Trimovate also contains Oxytetracycline, an antibiotic, and nystatin, an antifungal.[4][5][6]

Uses

In dermatology, topical clobestasone butyrate helps to reduce the itchiness and erythema associated with eczema and dermatitis.[7]

In ophthalmology, clobetasone butyrate 0.1% eye drops have been shown to be safe and effective in the treatment of dry eyes in Sjögren's Syndrome. Sjögren's Syndrome is an autoimmune disorder that affects the moisture producing glands of the body causing many symptoms including dry eyes.[8] When compared to other corticosteroid eye drops; clobetasone butyrate showed only minimal rises in intraocular pressure. Increased pressure within the eye can lead to glaucoma.[9][10][11]

Adverse effects

Side effects associated with clobetasone cream and ointment include: burning, irritation, itching, thinning of the skin, and changes in skin color.[12][13]

See also

References

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  1. ↑ United Nations Statistics Division - Classifications Registry - Alphabetical index for HS 2002 Entries starting with 'C' (page 310 of 422)
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Eumovate cream/ointment, NetDoctor.co.uk
  4. ↑ 30g Trimovate Cream Box, GSK
  5. ↑ Medicines.org.uk - Trimovate info
  6. ↑ Trimovate cream, NetDoctor.co.uk
  7. ↑ Euvomate Medication Guide, GlaxoSmithKline
  8. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  9. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  10. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  11. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  12. ↑ Clobetason Butyrate, WebMD
  13. ↑ Euvomate Medication Guide, GlaxoSmithKline
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