Deoxyribonuclease II

deoxyribonuclease II alpha
Identifiers
Symbol	DNASE2
Alt. symbols	DNASE2A, DRN2, DNL, DNL2
Entrez	1777
HUGO	2960
OMIM	126350
RefSeq	NM_001375
UniProt	O00115
Other data
EC number	3.1.22.1
Locus	Chr. 19 p13.2

deoxyribonuclease II beta
Identifiers
Symbol	DNASE2B
Entrez	58511
HUGO	28875
OMIM	608057
RefSeq	NM_021233
UniProt	Q8WZ79
Other data
EC number	3.1.22.1
Locus	Chr. 1 p22.3

Deoxyribonuclease II (EC 3.1.22.1, DNase II, pancreatic DNase II, deoxyribonucleate 3'-nucleotidohydrolase, pancreatic DNase II, acid deoxyribonuclease, acid DNase) hydrolyzes deoxyribonucleotide linkages in native and denatured DNA, yielding products with 3'-phosphates. As the name implies, it is more effective at acid pH.

There are several known DNases II, including:

• DNase II alpha (usually just called DNase II)
• DNase II beta (also called DLAD, or DNase II-Like Acid DNase)

External links

• deoxyribonuclease II at the US National Library of Medicine Medical Subject Headings (MeSH)