Dermoepidermal junction

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The dermoepidermal junction is the area of tissue that joins the epidermal and the dermal layers of the skin.^[1] The basal cells in the stratum basale of the epidermis connect to the basement membrane by the anchoring filaments of hemidesmosomes; the cells of the papillary layer of the dermis are attached to the basement membrane by anchoring fibrils, which consist of type VII collagen.^[2]

Stevens-Johnson syndrome and toxic epidermal necrolysis are diseases where there is a breakdown of the dermoepidermal junction.

References

Epidermis	Stratum corneum Stratum lucidum Stratum granulosum Stratum spinosum Stratum basale
Basement membrane	Basal keratinocyte Lamina lucida Lamina densa
Dermis	Papillary Dermal papillae Reticular

Root sheath	Outer root sheath Inner root sheath Henle's layer Huxley's layer
Hair shaft	Cuticle Cortex Medulla Bulb with matrix cells Hair follicle
Muscle	Arrector pili muscle
Pilosebaceous unit	Hair sebaceous gland

v t e Index of skin
Description	Anatomy Physiology connective tissue Development
Disease	Infections by morphology Vesiculobullous Dermatitis and eczema factitial Papulosquamous Urticaria and erythema Radiation-related Pigmentation Mucinoses Keratosis, ulcer, atrophy, and necrobiosis Vasculitis Fat Neutrophilic and eosinophilic Congenital Neoplasms and cancer nevi and melanomas epidermis dermis Symptoms and signs Terminology
Treatment	Procedures Drugs antibiotics disinfectants emollients and protectives itch psoriasis other Wound and ulcer

v t e Index of skin appendages
Description	Anatomy Physiology Development
Disease	Congenital Neoplasms and cancer Other Symptoms and signs
Treatment	Procedures Acne drugs

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