Fursultiamine

Fursultiamine

Systematic (IUPAC) name
N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-N-{(1E)-4-hydroxy-1-methyl-2-[(tetrahydrofuran-2-ylmethyl)disulfanyl]but-1-en-1-yl}formamide
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	OTC
Routes of administration	Oral
Identifiers
CAS Number	804-30-8
ATC code	None
PubChem	CID: 3002119
DrugBank	DB08966 N
ChemSpider	2273321
UNII	05J61265PX Y
ChEMBL	CHEMBL1740659
Chemical data
Formula	C17H26N4O3S2
Molecular mass	398.54 g/mol
SMILES O=CN(\C(=C(\SSCC1OCCC1)CCO)C)Cc2cnc(nc2N)C

Fursultiamine (INN; Adventan, Alinamin-F, Benlipoid, Bevitol Lipophil, Judolor), also known as thiamine tetrahydrofurfuryl disulfide (TTFD), is a disulfide derivative of thiamine, or an allithiamine. It was synthesized in Japan in the 1960s for the purpose of developing forms of thiamine with improved lipophilicity for treating vitamin B₁ deficiency (i.e., beriberi), and was subsequently commercialized not only in Japan but also in Spain, Austria, Germany, and the United States. As a vitamin, it is available over-the-counter as well.

In addition to its clinical indication of avitaminosis, fursultiamine has been studied in clinical trials for Alzheimer's disease and autistic spectrum disorders with positive but modest benefits. It has also been investigated in improving energy metabolism during exercise and reducing exercise-induced fatigue with conflicting results.

Available Brands: Privitamix softgel (India)

See also

• Vitamin B₁ analogue