ING5

Inhibitor of growth family, member 5
250px PDB rendering based on 1wen.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3C6W
Identifiers
Symbols	ING5 ; p28ING5
External IDs	OMIM: 608525 HomoloGene: 90955 GeneCards: ING5 Gene
Gene ontology Molecular function • chromatin binding • protein binding • zinc ion binding • methylated histone binding Cellular component • nucleus • nucleoplasm • MOZ/MORF histone acetyltransferase complex Biological process • DNA replication • chromatin organization • transcription, DNA-templated • protein acetylation • negative regulation of cell proliferation • positive regulation of apoptotic process • histone H3 acetylation • positive regulation of transcription, DNA-templated • negative regulation of growth • positive regulation of apoptotic signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84289	66262
Ensembl	ENSG00000168395	ENSMUSG00000026283
UniProt	Q8WYH8	Q9D8Y8
RefSeq (mRNA)	NM_032329	NM_025454
RefSeq (protein)	NP_115705	NP_079730
Location (UCSC)	Chr 2: 241.7 – 241.73 Mb	Chr 1: 93.8 – 93.82 Mb
PubMed search	[1]	[2]

Inhibitor of growth protein 5 is a protein that in humans is encoded by the ING5 gene.

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway.

Interactions

ING5 has been shown to interact with EP300 and P53.