LMTK2

Lemur tyrosine kinase 2
Identifiers
Symbols	LMTK2 ; AATYK2; BREK; KPI-2; KPI2; LMR2; PPP1R100; cprk
External IDs	OMIM: 610989 MGI: 3036247 HomoloGene: 8948 GeneCards: LMTK2 Gene
EC number	2.7.11.1
Gene ontology Molecular function • protein serine/threonine kinase activity • protein phosphatase inhibitor activity • protein binding • ATP binding • myosin VI binding Cellular component • early endosome • Golgi apparatus • integral component of membrane • perinuclear region of cytoplasm • recycling endosome Biological process • receptor recycling • protein phosphorylation • peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • endocytic recycling • transferrin transport • negative regulation of catalytic activity • early endosome to late endosome transport • protein autophosphorylation Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE LMTK2 206223 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22853	231876
Ensembl	ENSG00000164715	ENSMUSG00000038970
UniProt	Q8IWU2	Q3TYD6
RefSeq (mRNA)	NM_014916	NM_001081109
RefSeq (protein)	NP_055731	NP_001074578
Location (UCSC)	Chr 7: 98.11 – 98.21 Mb	Chr 5: 144.1 – 144.19 Mb
PubMed search	[1]	[2]

Serine/threonine-protein kinase LMTK2 also known as Lemur tyrosine kinase 2 (LMTK2) is an enzyme that in humans is encoded by the LMTK2 gene.

Function

The LMTK2 enzyme belongs to both the protein kinase and the tyrosine kinase families. It contains N-terminus transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as androgen receptor, inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosphorylates other proteins, and is itself also phosphorylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein is involved in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis.

Clinical significance

Loss of LMTK2 has been implicated to play a role in development of prostate cancer.

Interactions

LMTK2 has been shown to interact with PPP1CA, Cyclin-dependent kinase 5 and PPP1R2.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.