MMP21

Matrix metallopeptidase 21
Identifiers
Symbols	MMP21 ; MMP-21
External IDs	OMIM: 608416 MGI: 2664387 HomoloGene: 17519 GeneCards: MMP21 Gene
EC number	3.4.24.-
Gene ontology Molecular function • metalloendopeptidase activity • calcium ion binding • zinc ion binding Cellular component • extracellular region • extracellular matrix Biological process • hematopoietic progenitor cell differentiation • proteolysis Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE MMP21 gnf1h06009 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	118856	214766
Ensembl	ENSG00000154485	ENSMUSG00000030981
UniProt	Q8N119	Q8K3F2
RefSeq (mRNA)	NM_147191	NM_152944
RefSeq (protein)	NP_671724	NP_694423
Location (UCSC)	Chr 10: 125.77 – 125.78 Mb	Chr 7: 133.67 – 133.68 Mb
PubMed search	[1]	[2]

Matrix metalloproteinase-21 (MMP-21) is an enzyme that in humans is encoded by the MMP21 gene.

Function

This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling,and disease processes, such as asthma and metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival.

External links

• The MEROPS online database for peptidases and their inhibitors: M10.026