Major vault protein
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Major vault protein is a protein that in humans is encoded by the MVP gene.[1][2] 78 copies of the protein assemble into the large compartments called vaults, illustrated and discussed in the article on Vault (organelle).
Function
This gene encodes the major vault protein which is a lung infection resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.[2]
Interactions
Major vault protein has been shown to interact with Estrogen receptor alpha,[3] PTEN[4] and PARP4.[5][6]
References
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