Mazapertine

Mazapertine
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Names
	IUPAC name Piperidin-1-yl[3-({4-[2-(propan-2-yloxy)phenyl]piperazin-1-yl}methyl)phenyl]methanone
	Other names RWJ-37796
Identifiers
CAS Number	134208-17-6
ChEMBL	ChEMBL10085
ChemSpider	54808
Jmol 3D model	Interactive image
PubChem	60820
UNII	N0X1XW704P
	InChI InChI=1S/C26H35N3O2/c1-21(2)31-25-12-5-4-11-24(25)28-17-15-27(16-18-28)20-22-9-8-10-23(19-22)26(30)29-13-6-3-7-14-29/h4-5,8-12,19,21H,3,6-7,13-18,20H2,1-2H3 Key: ZKZFPRUSWCYSGT-UHFFFAOYSA-N ; InChI=1/C26H35N3O2/c1-21(2)31-25-12-5-4-11-24(25)28-17-15-27(16-18-28)20-22-9-8-10-23(19-22)26(30)29-13-6-3-7-14-29/h4-5,8-12,19,21H,3,6-7,13-18,20H2,1-2H3 Key: ZKZFPRUSWCYSGT-UHFFFAOYAF ;
	SMILES O=C(N1CCCCC1)c2cc(ccc2)CN4CCN(c3ccccc3OC(C)C)CC4 ;
Properties
Chemical formula	C26H35N3O2
Molar mass	421.59 g·mol−1
Vapor pressure	{{{value}}}
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

Mazapertine (RWJ-37796) is an antipsychotic agent that was developed by Johnson & Johnson but never marketed. It exerts its pharmacological effect through affinity for dopamine D₂, serotonin 5-HT_1A, and α₁-adrenergic receptors.^[1]

Mazapertine is safe and well tolerated when administered orally.^[2]

Analogs of mazapertine with conformational restriction have been prepared and have greater affinity for the 5-HT_1A receptor.^[3]

References

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