Mesterolone

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Mesterolone
Mesterolone.svg
Systematic (IUPAC) name
1α-Methyl-17β-hydroxy-5α-androstan-3-one
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
  • Prescription Only (AU)
Pharmacokinetic data
Metabolism Liver
Identifiers
CAS Number 1424-00-6 N
ATC code G03BB01 (WHO)
PubChem CID: 15020
ChemSpider 14296 YesY
UNII 0SRQ75X9I9 YesY
KEGG D04947 YesY
ChEMBL CHEMBL258918 YesY
Chemical data
Formula C20H32O2
Molecular mass 304.467 g/mol
  • O=C4C[C@@H]3CC[C@@H]2[C@H](CC[C@]1(C)[C@@H](O)CC[C@H]12)[C@@]3(C)[C@@H](C)C4
  • InChI=1S/C20H32O2/c1-12-10-14(21)11-13-4-5-15-16-6-7-18(22)19(16,2)9-8-17(15)20(12,13)3/h12-13,15-18,22H,4-11H2,1-3H3/t12-,13-,15-,16-,17-,18-,19-,20-/m0/s1 YesY
  • Key:UXYRZJKIQKRJCF-TZPFWLJSSA-N YesY
 NYesY (what is this?)  (verify)

Mesterolone is an orally applicable androgen and dihydrotestosterone (DHT) derivative. It is sold under the brand name Proviron (as Provironum in Asia-Pacific region), by Bayer Schering Pharma (earlier by Schering). In the late 70s and early 80s, it was used with some success in controlled studies of men suffering from various forms of depression. Mesterolone is a relatively weak androgen and rarely used for replacement therapies.[1]

Trials

In one small scale clinical trial of depressed patients, an improvement of symptoms which included anxiety, lack of drive and desire was observed.[2] In patients with dysthymia, unipolar, and bipolar depression significant improvement was observed.[2] In this series of studies, mesterolone lead to a significant decrease in LH and testosterone levels. In another study, 100 mg mesterolone cypionate was administered twice monthly. With regards to plasma T levels, there was no difference between the treated vs untreated group, and baseline LH levels were minimally affected.[3]

Bodybuilding

Mesterolone had seen widespread use in bodybuilding primarily for antiestrogenic activity in anabolic steroid stacks but such use has declined after introduction of aromatase inhibitors and SERMs. Most significant benefits of current Mesterolone use are considered by bodybuilders to be maintaining libido off-cycle and also relatively and temporarily improving vascularity.[4]

See also

  • SH-434 (17-propylmesterolone) (17 beta-hydroxy-1 alpha-methyl-17 alpha-propyl-5 alpha-androstan-3-one). antiandrogen[5]

References

  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ 2.0 2.1 Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Meso-RX Steroid Profiles - Proviron (Mesterolone)
  5. ↑ Lua error in package.lua at line 80: module 'strict' not found.

Further reading

  • Lua error in package.lua at line 80: module 'strict' not found.
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