Mitochondrial ferritin

Ferritin mitochondrial
Crystallographic structure of mitochondrial ferritin.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1R03
Identifiers
Symbols	FTMT ; MTF
External IDs	OMIM: 608847 MGI: 1914884 HomoloGene: 110661 GeneCards: FTMT Gene
EC number	1.16.3.1
Gene ontology Molecular function • ferroxidase activity • ferric iron binding Cellular component • nucleus • mitochondrion Biological process • iron ion transport • cellular iron ion homeostasis • positive regulation of cell proliferation • positive regulation of lyase activity • oxidation-reduction process • positive regulation of succinate dehydrogenase activity • positive regulation of aconitate hydratase activity Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	94033	67634
Ensembl	ENSG00000181867	ENSMUSG00000024510
UniProt	Q8N4E7	Q9D5H4
RefSeq (mRNA)	NM_177478	NM_026286
RefSeq (protein)	NP_803431	NP_080562
Location (UCSC)	Chr 5: 121.85 – 121.85 Mb	Chr 18: 52.33 – 52.33 Mb
PubMed search	[1]	[2]

Mitochondrial ferritin is a ferroxidase enzyme that in humans is encoded by the FTMT gene.

It is classified as a metal-binding protein which is located within the mitochondria. After the protein is taken up by the mitochondria it can be processed into a mature protein and assemble functional ferritin shells.

Structure

Its structure was determined at 1.70 Å through the use of X-ray diffraction and contains 182 residues. It is 67% helical. The Ramachandran plot shows that the structure of mitochondrial ferritin is mainly alpha helical with a low prevalence of beta sheets.