NCOA5

Nuclear receptor coactivator 5
250px PDB rendering based on 1v95.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1V95, 2J7X, 2J7Y
Identifiers
Symbols	NCOA5 ; CIA; bA465L10.6
External IDs	MGI: 2385165 HomoloGene: 32496 GeneCards: NCOA5 Gene
Gene ontology Molecular function • chromatin binding • protein binding • poly(A) RNA binding Cellular component • extracellular space • nucleus • nucleoplasm • actin cytoskeleton Biological process • transcription, DNA-templated • regulation of transcription, DNA-templated • glucose homeostasis • negative regulation of insulin receptor signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57727	228869
Ensembl	ENSG00000124160	ENSMUSG00000039804
UniProt	Q9HCD5	Q91W39
RefSeq (mRNA)	NM_020967	NM_144892
RefSeq (protein)	NP_066018	NP_659141
Location (UCSC)	Chr 20: 46.06 – 46.09 Mb	Chr 2: 165 – 165.03 Mb
PubMed search	[1]	[2]

Nuclear receptor coactivator 5 (NCOA5), also known as coactivator independent of AF-2 function (CIA), is a protein that in humans is encoded by the NCOA5 gene.

Function

This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor Rev-ErbA beta. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined.

External links

• NCOA5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• NURSA C93

This article incorporates text from the United States National Library of Medicine, which is in the public domain.