PLA2R1

Phospholipase A2 receptor 1, 180kDa
Identifiers
Symbols	PLA2R1 ; CLEC13C; PLA2-R; PLA2G1R; PLA2IR; PLA2R
External IDs	OMIM: 604939 MGI: 102468 HomoloGene: 32016 GeneCards: PLA2R1 Gene
Gene ontology Molecular function • receptor activity • carbohydrate binding • phospholipase binding Cellular component • extracellular region • plasma membrane • integral component of plasma membrane • cell surface • integral component of membrane • receptor complex • extracellular exosome Biological process • cytokine production • endocytosis • receptor-mediated endocytosis • positive regulation of DNA damage response, signal transduction by p53 class mediator • reactive oxygen species metabolic process • positive regulation of arachidonic acid secretion • replicative senescence • oxidative stress-induced premature senescence • negative regulation of phospholipase A2 activity • negative regulation of arachidonic acid secretion Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE PLA2R1 210194 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22925	18779
Ensembl	ENSG00000153246	ENSMUSG00000102781
UniProt	Q13018	Q62028
RefSeq (mRNA)	NM_001007267	NM_008867
RefSeq (protein)	NP_001007268	NP_032893
Location (UCSC)	Chr 2: 159.93 – 160.06 Mb	Chr 2: 60.42 – 60.55 Mb
PubMed search	[1]	[2]

Secretory phospholipase A2 receptor is an enzyme that in humans is encoded by the PLA2R1 gene.

Clinical significance

M-type phospholipase A2 receptor is the major antigen in idiopathic membranous nephropathy attributed to over 70% of cases.