PTPN12
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Tyrosine-protein phosphatase non-receptor type 12 is an enzyme that in humans is encoded by the PTPN12 gene.[1][2]
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein–protein interaction domain, and may be related to protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenesis. This PTP was shown to interact with, and dephosphorylate, various of cytoskeleton and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin, which suggested its regulatory roles in controlling cell shape and mobility.[2]
Interactions
PTPN12 has been shown to interact with BCAR1,[3][4][5][6] Grb2,[7] PSTPIP1,[8] TGFB1I1,[9] Paxillin[10][11][12] and SHC1.[13][14]
References
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Further reading
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