Precursor B-cell lymphoblastic leukemia
| Precursor B-cell lymphoblastic leukemia | |
|---|---|
A Wright's stained bone marrow aspirate smear from a person with precursor B-cell acute lymphoblastic leukemia.
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| Classification and external resources | |
| Specialty | Lua error in Module:Wikidata at line 247: invalid escape sequence near '"^'. |
| ICD-10 | C83.5 |
| ICD-O | M9836/3 |
| Patient UK | Precursor B-cell lymphoblastic leukemia |
| MeSH | D015452 |
Precursor B-cell lymphoblastic leukemia is a form of lymphoid leukemia in which too many B-cell lymphoblasts (immature white blood cells) are found in the blood and bone marrow. It is the most common type of acute lymphoblastic leukemia (ALL). It is sometimes additionally classified as a lymphoma, as designated leukemia/lymphoma.
It consists of the following subtypes:[1]
- t(9;22)-BCR/ ABL
- t(v;11q23)-MLL rearrangement
- t(1;19)-E2A/PBX1
- t(12;21)-ETV/ CBFα
- t(17;19)-E2A-HLF
Molecular Mechanisms
One interesting model of precursor B ALL shows aberrant function of a single gene, namely Pax5, as capable to change phenotype of B cells toward precursor cells.[2][3]
References
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This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".
External links
- Precursor B-lymphoblastic leukemia entry in the public domain NCI Dictionary of Cancer Terms
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