REG3G

Regenerating islet-derived 3 gamma
Identifiers
Symbols	REG3G ; LPPM429; PAP IB; PAP-1B; PAP1B; PAPIB; REG III; REG-III; UNQ429
External IDs	OMIM: 609933 MGI: 109408 HomoloGene: 128216 GeneCards: REG3G Gene
Gene ontology Molecular function • carbohydrate binding Cellular component • extracellular region • cytoplasm Biological process • MyD88-dependent toll-like receptor signaling pathway • acute-phase response • positive regulation of keratinocyte proliferation • negative regulation of keratinocyte differentiation • defense response to Gram-positive bacterium • positive regulation of wound healing Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE REG3G gnf1h03867 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	130120	19695
Ensembl	ENSG00000143954	ENSMUSG00000030017
UniProt	Q6UW15	O09049
RefSeq (mRNA)	NM_001008387	NM_011260
RefSeq (protein)	NP_001008388	NP_035390
Location (UCSC)	Chr 2: 79.03 – 79.03 Mb	Chr 6: 78.47 – 78.47 Mb
PubMed search	[1]	[2]

Regenerating islet-derived protein 3 gamma is a protein that in humans is encoded by the REG3G gene.

Intestinal paneth cells produce REG3G (or REG3 gamma) via stimulation of toll-like receptors (TLRs) by pathogen-associated molecular patterns (PAMPs). REG3 gamma specifically targets Gram-positive bacteria because it binds to their surface peptidoglycan layer. It is one of several antimicrobial peptides produced by paneth cells.