RHOB

Ras homolog family member B
Ras homolog family member B
	PDB rendering based on 2fv8.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	2FV8
Identifiers
Symbols	RHOB ; ARH6; ARHB; MST081; MSTP081; RHOH6
External IDs	OMIM: 165370 MGI: 107949 HomoloGene: 68377 ChEMBL: 1795102 GeneCards: RHOB Gene
EC number	3.6.1.47
Gene ontology
Molecular function	• GTPase activity; • protein binding; • GTP binding; • GDP binding;
Cellular component	• nucleus; • early endosome; • cytosol; • plasma membrane; • focal adhesion; • endosome membrane; • late endosome membrane; • cleavage furrow; • extracellular exosome;
Biological process	• cytokinesis; • angiogenesis; • intracellular protein transport; • apoptotic process; • transformed cell apoptotic process; • cell adhesion; • small GTPase mediated signal transduction; • Rho protein signal transduction; • axon guidance; • blood coagulation; • endosome to lysosome transport; • platelet activation; • positive regulation of apoptotic process; • positive regulation of angiogenesis; • negative regulation of cell cycle; • regulation of small GTPase mediated signal transduction; • cellular response to hydrogen peroxide; • cellular response to ionizing radiation;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
Species	Human
Entrez	388
Ensembl	ENSG00000143878
UniProt	P62745
RefSeq (mRNA)	NM_004040
RefSeq (protein)	NP_004031
Location (UCSC)	Chr 2:; 20.45 – 20.45 Mb
PubMed search	[1]
	v; t; e;

Ras homolog gene family, member B, also known as RHOB, is a protein which in humans is encoded by the RHOB gene.^[1]^[2]

RHOB is a member of the Rho GTP-binding protein family.^[3]

Interactions

RHOB has been shown to interact with CIT,^[4] ARHGEF3,^[5] ARHGDIG^[6] and RHPN2.^[7]