Template:PBB/5781

Protein tyrosine phosphatase, non-receptor type 11
250px PDB rendering based on 2shp.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2SHP, 3B7O, 3MOW, 3O5X, 3TKZ, 3TL0, 3ZM0, 3ZM1, 3ZM2, 3ZM3, 4DGP, 4DGX, 4GWF, 4H1O, 4H34, 4JE4, 4JEG, 4JMG, 4NWF, 4NWG, 4OHD, 4OHE, 4OHH, 4OHI, 4OHL, 4PVG
Identifiers
Symbols	PTPN11 ; BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
External IDs	OMIM: 176876 MGI: 99511 HomoloGene: 2122 ChEMBL: 3864 GeneCards: PTPN11 Gene
EC number	3.1.3.48
Gene ontology Molecular function • phosphoprotein phosphatase activity • protein tyrosine phosphatase activity • non-membrane spanning protein tyrosine phosphatase activity • SH3/SH2 adaptor activity • insulin receptor binding • protein binding • protein domain specific binding • receptor tyrosine kinase binding • D1 dopamine receptor binding • phospholipase binding • insulin receptor substrate binding • peptide hormone receptor binding Cellular component • nucleus • cytoplasm • mitochondrion • cytosol • protein complex Biological process • DNA damage checkpoint • activation of MAPK activity • triglyceride metabolic process • epidermal growth factor receptor signaling pathway • integrin-mediated signaling pathway • axon guidance • brain development • heart development • blood coagulation • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway • hormone-mediated signaling pathway • cytokine-mediated signaling pathway • platelet formation • T cell costimulation • microvillus organization • abortive mitotic cell cycle • regulation of cell adhesion mediated by integrin • negative regulation of cell adhesion mediated by integrin • multicellular organism growth • organ growth • peptidyl-tyrosine dephosphorylation • megakaryocyte development • atrioventricular canal development • Fc-epsilon receptor signaling pathway • ERBB signaling pathway • regulation of multicellular organism growth • hormone metabolic process • glucose homeostasis • innate immune response • positive regulation of mitotic cell cycle • negative regulation of insulin secretion • regulation of protein export from nucleus • positive regulation of hormone secretion • platelet-derived growth factor receptor signaling pathway • neurotrophin TRK receptor signaling pathway • ephrin receptor signaling pathway • phosphatidylinositol-mediated signaling • multicellular organismal reproductive process • genitalia development • inner ear development • homeostasis of number of cells within a tissue • leukocyte migration • negative regulation of cortisol secretion • negative regulation of growth hormone secretion • face morphogenesis • interferon-gamma-mediated signaling pathway • regulation of interferon-gamma-mediated signaling pathway • type I interferon signaling pathway • regulation of type I interferon-mediated signaling pathway • intestinal epithelial cell migration • positive regulation of ERK1 and ERK2 cascade • positive regulation of glucose import in response to insulin stimulus Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE PTPN11 gnf1h09380 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5781	19247
Ensembl	ENSG00000179295	ENSMUSG00000043733
UniProt	Q06124	P35235
RefSeq (mRNA)	NM_002834	NM_001109992
RefSeq (protein)	NP_002825	NP_001103462
Location (UCSC)	Chr 12: 112.42 – 112.51 Mb	Chr 5: 121.13 – 121.19 Mb
PubMed search	[1]	[2]