Tony Kouzarides

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Tony Kouzarides
Born (1958-01-17) 17 January 1958 (age 67)[1]
Fields Cancer
Chromatin
Transcription
Institutions University of Leeds
University of Cambridge
Gurdon Institute
New York University
Laboratory of Molecular Biology
Abcam
Alma mater University of Leeds (BSc)
University of Cambridge (PhD)
Thesis A molecular analysis of transformation by human cytomegalovirus (1985)
Doctoral advisor Tony Minson[2]
Doctoral students Jacqui Sutherland[3]
Helen Brown[4]
Juliet Reid [5]
Klaus Martin[6][7]
Eric Miska[8]
Philip Zegerman[9][10]
Wendy Bergers
Dan Wolf[11]
Graeme Cuthbert[12]
Karen Halls
Claire Pike[13]
Other notable students (postdocs)
Christian Hagemeier[14]
Didier Trouche[15]
Jonathan Milner[16][17]
Alex Brehm[18]
Catherine Le Chalony
Søren Neilson
Paul Lavender[19]
Francois Fuks[20]
Marian Martinez Balbas
Laurence Vandel[21]
Uta-Maria Bauer[22]
Guida Ruas
Emma Langley[23]
Sylvain Daujat[24]
Luke Hughes-Davies[25]
Robert Schneider[26]
Steve Sanders[27]
Susana Lopes
Chris Nelson[28]
Paul Hurd[29]
Sopie Deltour
David Lando[30]
Antonis Kirmizis[31][32]
Hatice Akarsu
Blerta Xhemalce[33]
Till Bartke[34]
Marc Schneider
Gonçalo Castelo-Branco[13]
Notable awards Heinrich Wieland Prize (2013)
Fellow of the Royal Society (2012)[35]
FMedSci (2001)[36]
Spouse Penny Hall[1]
Website
www.gurdon.cam.ac.uk/~kouzarideslab
royalsociety.org/people/tony-kouzarides

Tony Kouzarides, FMedSci,[36] FRS[35] (born 17 January 1958) is the deputy director of the Gurdon Institute,[37] a founding non-executive director of Abcam[38] and a Professor of Cancer Biology at the University of Cambridge.[39][40]

Education

Kouzarides was educated at the University of Leeds, graduating with a Bachelor of Science degree in Genetics in 1981.[1] He went on to complete his PhD at the University of Cambridge in 1985.[41]

Research

Following his PhD, Kouzarides did postdoctoral work at the Laboratory of Molecular Biology (LMB) on the cancer potential of cytomegalovirus.[42] and then on to New York University Medical Center. Here he examined the c-Fos leucine zipper dimerisation domain to elucidate its function. He got a job at the Gurdon Institute in Cambridge, where he has been since.[43]

Kouzarides is a leader in the field of chromatin modification[44] and its role in transcriptional control and cancer.[45][46] In 1996 he made a key discovery in finding that the transcriptional co-activator CBP[47] is a histone acetyltransferase.[48][49] He has since worked on identifying several new histone modifications, describing their functions in transcription and DNA repair and highlighting their mis-regulation in cancer. His demonstration that a histone acetylation pathway inhibitor can be used to treat MLL-leukaemias in has facilitated its use in clinical trials.[35]

Awards

Kouzarides was elected a member of the Academy of Medical Sciences (FMedSci) in 2001[36] a Fellow of the Royal Society (FRS) in 2012.[35] His nomination read:<templatestyles src="Template:Blockquote/styles.css" />

"Tony Kouzarides is world leader in the field of chromatin modification and its roles in transcriptional control and cancer. His finding in 1996 that the transcriptional co-activator CBP is a histone acetyltransferase was one of the key discoveries that started the modern era of chromatin research. His subsequent work has identified several new histone modifications, described their functions in transcription and DNA repair and has highlighted their mis-regulation in cancer. His demonstration that a histone acetylation pathway inhibitor is an effective treatment for MLL-leukaemias in disease models has opened the way to its use in clinical trials."[35]

Kouzarides was also awarded the Sanofi-Cell Research Outstanding Paper Award of 2011[50] for his paper on Regulation of chromatin by histone modifications co-authored with Andrew Bannister.[51]

In 2013, he was awarded the Heinrich Wieland Prize for his pioneering "research on gene regulation and cancer"[52]

References

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  36. ↑ 36.0 36.1 36.2 Lua error in package.lua at line 80: module 'strict' not found.
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  46. ↑ http://www.ncbi.nlm.nih.gov/pubmed?term=kouzarides Kouzarides in PubMed
  47. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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  52. ↑ Heinrich Wieland Prize; accessed 18 March 2015. (German)
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