WAY-267464
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Systematic (IUPAC) name | |
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4-(3,5-Dihydroxybenzyl)-N-(2-methyl-4-[(1-methyl-4,10-dihydropyrazolo[3,4-b][1,5]benzodiazepin-5(1H)-yl)carbonyl]benzyl)piperazine-1-carboxamide
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Identifiers | |
CAS Number | 847375-16-0 |
ATC code | none |
PubChem | CID: 9938214 |
ChemSpider | 31047382 |
Chemical data | |
Formula | C32H35N7O4 |
Molecular mass | 581.677 g/mol |
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WAY-267464 is a potent, selective, non-peptide agonist for the oxytocin receptor, with negligible affinity for the vasopressin receptors.[1][2] Contradictorily however, though originally described as selective for the oxytocin receptor and lacking affinity for the vasopressin receptors, it has since been reported to also act as a potent vasopressin V1A receptor antagonist (in contrast to oxytocin, which is a weak agonist of the V1A receptor).[3] WAY-267464 has been shown to cross the blood-brain-barrier to a significantly greater extent than exogenously applied oxytocin, and in animal tests produces centrally-mediated oxytocinergic actions such as anxiolytic effects, but with no antidepressant effect evident.[4] It was developed by a team at Ferring Pharmaceuticals.[5]
WAY-267464 is or was under investigation for the potential clinical treatment of anxiety disorders by Wyeth.[1]
See also
References
- ↑ Rahman Z, Resnick L, Rosenzweig-Lipson SJ, Ring RH,"Methods of treatment using oxytocin receptor agonists", US patent application 2007/0117794, published 2007-05-24 , assigned to Wyeth Corp
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- ↑ European Patent 1512687 Piperazines as oxytocin agonists
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- Drugs not assigned an ATC code
- Anxiolytics
- Resorcinols
- Piperazines
- Amides
- Benzodiazepines
- Oxytocin receptor agonists
- Vasopressin receptor antagonists
- Genito-urinary system drug stubs
- Nervous system drug stubs