CELA2B
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| Chymotrypsin-like elastase family, member 2B | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | CELA2B ; ELA2B | ||||||||||||
| External IDs | OMIM: 609444 HomoloGene: 88835 ChEMBL: 3887 GeneCards: CELA2B Gene | ||||||||||||
| EC number | 3.4.21.71 | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 51032 | n/a | |||||||||||
| Ensembl | ENSG00000215704 | n/a | |||||||||||
| UniProt | P08218 | n/a | |||||||||||
| RefSeq (mRNA) | NM_015849 | n/a | |||||||||||
| RefSeq (protein) | NP_056933 | n/a | |||||||||||
| Location (UCSC) | Chr 1: 15.47 – 15.49 Mb |
n/a | |||||||||||
| PubMed search | [1] | n/a | |||||||||||
Chymotrypsin-like elastase family member 2B is and enzyme that in humans is encoded by the CELA2B gene.[1][2][3]
Function
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2B is secreted from the pancreas as a zymogen. In other species, elastase 2B has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues.[3]
References
Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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