Zyxin
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Zyxin is a protein that in humans is encoded by the ZYX gene.[1][2][3]
Function
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.[3]
Interactions
Zyxin has been shown to interact with:
- Actinin, alpha 1[4][5]
- ENAH,[6][7]
- LASP1,[8]
- LATS1,[9] and
- Vasodilator-stimulated phosphoprotein.[7][10]
References
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Further reading
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External links
- Zyxin Info with links in the Cell Migration Gateway
