AMG-1

AMG-1

Systematic (IUPAC) name
(6aR,10aR)-3-(hept-1-ynyl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
Identifiers
PubChem	CID: 10830874
ChemSpider	9006174 Y
ChEMBL	CHEMBL279147 Y
Chemical data
Formula	C23H30O2
Molecular mass	338.482 g/mol
SMILES CC=3CC1c2c(O)cc(C#CCCCCC)cc2OC(C)(C)C1CC=3
InChI InChI=1S/C23H30O2/c1-5-6-7-8-9-10-17-14-20(24)22-18-13-16(2)11-12-19(18)23(3,4)25-21(22)15-17/h11,14-15,18-19,24H,5-8,12-13H2,1-4H3/t18-,19-/m1/s1 Y Key:PYCLMAJRHLLHNO-RTBURBONSA-N Y
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AMG-1 is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8THC with a rigidified and extended 3-position side chain. AMG-1 is a potent agonist at both CB₁ and CB₂ with moderate selectivity for CB₁, with a K_i of 0.6nM at CB₁ vs 3.1nM at CB₂.