Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Beta-actin (human gene and protein symbol ACTB/ACTB) is one of six different actin isoforms which have been identified in humans. This is one of the two nonmuscle cytoskeletal actins. Actins are highly conserved proteins[1][2] that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.[3]
Interactions
Beta-actin has been shown to interact with SPTBN2.[4][5] In addition, RNA-binding protein Sam68 was found to interact with the mRNA encoding β-actin, which regulates the synaptic formation of the dendritic spines with its cytoskeletal components.
Beta-actin has been shown to activate eNOS, thereby increasing NO production. An eight-amino acid residue (326-333) in actin has been shown to mediate the interaction between actin and eNOS[6]
Clinical relevance
Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.[7]
Applications
Beta actin is usually used as a loading control, for among others, the integrity of cells, protein degradation, in PCR and Western blotting. Its molecular weight is approximately 42 kDa.
References
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Further reading
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See also
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PDB gallery
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1atn: Atomic structure of the actin:DNASE I complex
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1c0f: CRYSTAL STRUCTURE OF DICTYOSTELIUM CAATP-ACTIN IN COMPLEX WITH GELSOLIN SEGMENT 1
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1c0g: CRYSTAL STRUCTURE OF 1:1 COMPLEX BETWEEN GELSOLIN SEGMENT 1 AND A DICTYOSTELIUM/TETRAHYMENA CHIMERA ACTIN (MUTANT 228: Q228K/T229A/A230Y/E360H)
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1d4x: Crystal Structure of Caenorhabditis Elegans Mg-ATP Actin Complexed with Human Gelsolin Segment 1 at 1.75 A resolution.
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1dej: CRYSTAL STRUCTURE OF A DICTYOSTELIUM/TETRAHYMENA CHIMERA ACTIN (MUTANT 646: Q228K/T229A/A230Y/A231K/S232E/E360H) IN COMPLEX WITH HUMAN GELSOLIN SEGMENT 1
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1eqy: COMPLEX BETWEEN RABBIT MUSCLE ALPHA-ACTIN: HUMAN GELSOLIN DOMAIN 1
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1esv: COMPLEX BETWEEN LATRUNCULIN A:RABBIT MUSCLE ALPHA ACTIN:HUMAN GELSOLIN DOMAIN 1
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1h1v: GELSOLIN G4-G6/ACTIN COMPLEX
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1hlu: STRUCTURE OF BOVINE BETA-ACTIN-PROFILIN COMPLEX WITH ACTIN BOUND ATP PHOSPHATES SOLVENT ACCESSIBLE
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1ijj: THE X-RAY CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN RABBIT SKELETAL MUSCLE ACTIN AND LATRUNCULIN A AT 2.85 A RESOLUTION
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1kxp: CRYSTAL STRUCTURE OF HUMAN VITAMIN D-BINDING PROTEIN IN COMPLEX WITH SKELETAL ACTIN
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1lcu: Polylysine Induces an Antiparallel Actin Dimer that Nucleates Filament Assembly: Crystal Structure at 3.5 A Resolution
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1lot: CRYSTAL STRUCTURE OF THE COMPLEX OF ACTIN WITH VITAMIN D-BINDING PROTEIN
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1m8q: Molecular Models of Averaged Rigor Crossbridges from Tomograms of Insect Flight Muscle
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1ma9: Crystal structure of the complex of human vitamin D binding protein and rabbit muscle actin
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1mdu: Crystal structure of the chicken actin trimer complexed with human gelsolin segment 1 (GS-1)
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1mvw: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
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1nlv: Crystal Structure Of Dictyostelium Discoideum Actin Complexed With Ca ATP And Human Gelsolin Segment 1
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1nm1: Crystal Structure of D. Dicsoideum Actin Complexed With Gelsolin Segment 1 and Mg ATP at 1.8 A Resolution
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1nmd: Crystal Structure of D. Discoideum Actin-Gelsolin Segment 1 Complex Crystallized In Presence Of Lithium ATP
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1nwk: CRYSTAL STRUCTURE OF MONOMERIC ACTIN IN THE ATP STATE
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1o18: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
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1o19: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
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1o1a: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
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1o1b: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
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1o1c: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
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1o1d: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
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1o1e: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
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1o1f: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
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1o1g: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
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1p8z: Complex Between Rabbit Muscle alpha-Actin: Human Gelsolin Residues Val26-Glu156
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1qz5: Structure of rabbit actin in complex with kabiramide C
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1qz6: Structure of rabbit actin in complex with jaspisamide A
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1rdw: Actin Crystal Dynamics: Structural Implications for F-actin Nucleation, Polymerization and Branching Mediated by the Anti-parallel Dimer
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1rfq: Actin Crystal Dynamics: Structural Implications for F-actin Nucleation, Polymerization and Branching Mediated by the Anti-parallel Dimer
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1rgi: Crystal structure of gelsolin domains G1-G3 bound to actin
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1s22: Absolute Stereochemistry of Ulapualide A
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1sqk: CRYSTAL STRUCTURE OF CIBOULOT IN COMPLEX WITH SKELETAL ACTIN
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1t44: Structural basis of actin sequestration by thymosin-B4: Implications for arp2/3 activation
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1wua: The structure of Aplyronine A-actin complex
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1y64: Bni1p Formin Homology 2 Domain complexed with ATP-actin
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1yxq: Crystal structure of actin in complex with swinholide A
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2a3z: Ternary complex of the WH2 domain of WASP with Actin-DNAse I
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2a40: Ternary complex of the WH2 domain of WAVE with Actin-DNAse I
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2a41: Ternary complex of the WH2 Domain of WIP with Actin-DNAse I
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2a42: Actin-DNAse I Complex
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2a5x: Crystal Structure of a Cross-linked Actin Dimer
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2asm: Structure of Rabbit Actin In Complex With Reidispongiolide A
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2aso: Structure of Rabbit Actin In Complex With Sphinxolide B
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2asp: Structure of Rabbit Actin In Complex With Reidispongiolide C
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2btf: THE STRUCTURE OF CRYSTALLINE PROFILIN-BETA-ACTIN
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2d1k: Ternary complex of the WH2 domain of mim with actin-dnase I
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2ff3: Crystal structure of Gelsolin domain 1:N-wasp V2 motif hybrid in complex with actin
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2ff6: Crystal structure of Gelsolin domain 1:ciboulot domain 2 hybrid in complex with actin
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2fxu: X-ray Structure of Bistramide A- Actin Complex at 1.35 A resolution.
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2gwj: SpvB ADP-ribosylated actin: hexagonal crystal form
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2gwk: SpvB ADP-ribosylated actin: orthorhombic crystal form
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2hf3: Crystal structure of monomeric Actin in the ADP bound state
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2hf4: Crystal structure of Monomeric Actin in its ATP-bound state
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2hmp: Uncomplexed actin cleaved with protease ECP32
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2oan: Structure of oxidized beta-actin
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2q1n: Actin Dimer Cross-linked Between Residues 41 and 374
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2q31: Actin Dimer Cross-linked Between Residues 41 and 374 and proteolytically cleaved by subtilisin between residues 47 and 48.
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2q36: Actin Dimer Cross-linked between Residues 191 and 374 and complexed with Kabiramide C
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Index of cells
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| Description |
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| Disease |
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