Keratin 10

Keratin 10
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3ASW, 4F1Z
Identifiers
Symbols	KRT10 ; BCIE; BIE; CK10; EHK; K10; KPP
External IDs	OMIM: 148080 MGI: 96685 HomoloGene: 20125 GeneCards: KRT10 Gene
Gene ontology Molecular function • structural molecule activity • structural constituent of epidermis Cellular component • cytoplasm • intermediate filament • keratin filament Biological process • epidermis development • keratinocyte differentiation • cellular response to calcium ion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3858	16661
Ensembl	ENSG00000186395	ENSMUSG00000019761
UniProt	P13645	P02535
RefSeq (mRNA)	NM_000421	NM_010660
RefSeq (protein)	NP_000412	NP_034790
Location (UCSC)	Chr 17: 38.97 – 38.98 Mb	Chr 11: 99.39 – 99.39 Mb
PubMed search	[1]	[2]

Keratin, type I cytoskeletal 10 also known as cytokeratin-10 (CK-10) or keratin-10 (K10) is a protein that in humans is encoded by the KRT10 gene. Keratin 10 is a type I keratin.

Function

Keratin-10 is a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.

Interactions

Keratin 10 has been shown to interact with AKT1.

See also

• 34βE12 (keratin 903)