Bevenopran

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Bevenopran
Bevenopran.svg
Systematic (IUPAC) name
5-[2-Methoxy-4-[[2-(oxan-4-yl)ethylamino]methyl]phenoxy]pyrazine-2-carboxamide
Clinical data
Legal status
  • Investigational
Identifiers
CAS Number 676500-67-7
PubChem CID: 10452732
ChemSpider 8628148
Chemical data
Formula C20H26N4O4
Molecular mass 386.44484 g/mol
  • COC1=C(C=CC(=C1)CNCCC2CCOCC2)OC3=NC=C(N=C3)C(=O)N
  • InChI=1S/C20H26N4O4/c1-26-18-10-15(11-22-7-4-14-5-8-27-9-6-14)2-3-17(18)28-19-13-23-16(12-24-19)20(21)25/h2-3,10,12-14,22H,4-9,11H2,1H3,(H2,21,25)
  • Key:ZGCYVRNZWGUXNQ-UHFFFAOYSA-N

Bevenopran (INN, USAN) (former developmental code names CB-5945, ADL-5945, MK-2402, OpRA III) is a peripherally selective μ- and δ-opioid receptor antagonist that was under development by Cubist Pharmaceuticals for the treatment of chronic opioid-induced constipation.[1][2][3] It reached phase III clinical trials for this indication before being discontinued.[4][5]

See also

References

  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Combating Opioid-Induced Constipation: New and Emerging Therapies
  5. ↑ Bevenopran



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