Pericine

Pericine

Systematic (IUPAC) name
(R-(E))-5-ethylidcene-1,4,5,6,7,8-hexahydro-7-methylene-2H-3,6-ethanoazonino(5,4-b)indole
Clinical data
Legal status	Legal
Routes of administration	Oral
Identifiers
CAS Number	84638-28-8 Y
ATC code	none
PubChem	CID: 6440735
ChemSpider	4944986
Chemical data
Formula	C19H22N2
Molecular mass	278.391 g/mol
SMILES C\C=C/1\CN2CC[C@H]1C(=C)C3=C(CC2)C4=CC=CC=C4N3
InChI InChI=1S/C19H22N2/c1-3-14-12-21-10-8-15(14)13(2)19-17(9-11-21)16-6-4-5-7-18(16)20-19/h3-7,15,20H,2,8-12H2,1H3/b14-3-/t15-/m0/s1 Key:VAUGOKMDSLQYNG-WNDJQJCJSA-N
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Pericine is one of a number of indole alkaloids found in the tree Picralima nitida, commonly known as Akuamma. The dried seeds from this plant are used in traditional medicine throughout West Africa, particularly in Ghana as well as in the Ivory Coast and Nigeria. As with some other alkaloids from this plant such as akuammine, pericine has been shown to bind to mu opioid receptors, and has an IC₅₀ of 0.6 μmol, around 6x more potent than codeine when tested in the same assay. However it may also have convulsant effects.

See also

• Conolidine