Bradykinin receptor B2
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Bradykinin receptor B2 is a G-protein coupled receptor for bradykinin, encoded by the BDKRB2 gene in humans.
Mechanism
The B2 receptor is a G protein-coupled receptor, probably coupled to Gq and Gi. Gq stimulates phospholipase C to increase intracellular free calcium and Gi inhibits adenylate cyclase. Furthermore, the receptor stimulates the mitogen-activated protein kinase pathways. It is ubiquitously and constitutively expressed in healthy tissues.
The B2 receptor forms a complex with angiotensin converting enzyme (ACE), and this is thought to play a role in cross-talk between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS). The heptapeptide angiotensin 1-7 (A1-7) also potentiates bradykinin action on B2 receptors.[1]
Kallidin also signals through the B2 receptor. An antagonist for the receptor is Hoe 140 (icatibant).[2]
Function
The 9 amino acid bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation.
Gene
Alternate start codons result in two isoforms of the protein.[3]
See also
References
External links
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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