Neuromedin U receptor
From Infogalactic: the planetary knowledge core
neuromedin U receptor 1 | |
---|---|
Identifiers | |
Symbol | NMUR1 |
Alt. symbols | GPR66 |
Entrez | 10316 |
HUGO | 4518 |
OMIM | 604153 |
RefSeq | NM_006056 |
UniProt | Q9HB89 |
Other data | |
Locus | Chr. 2 q37.1 |
neuromedin U receptor 2 | |
---|---|
Identifiers | |
Symbol | NMUR2 |
Alt. symbols | NMU2R |
Entrez | 56923 |
HUGO | 16454 |
OMIM | 605108 |
RefSeq | NM_020167 |
UniProt | Q9GZQ4 |
Other data | |
Locus | Chr. 5 q33.1 |
The neuromedin U receptors are two G-protein coupled receptors which bind the neuropeptide hormones neuromedin U and neuromedin S.[1] There are two subtypes of the neuromedin U receptor, each encoded by a separate gene (NMUR1, NMUR2).
Selective Ligands
Neuromedin U is an agonist at both the NMU1 and NMU2 subtypes, while neuromedin S is selective for NMU2, and is a more potent agonist at this subtype than neuromedin U.[2][3] Several other peptide and non-peptide ligands are also available for the NMU receptors.
Agonists
- Non-selective
- Neuromedin U
- non-peptide NMU modulators [4][5]
- NMU2 selective
Antagonists
- NMU2 selective
- R-PSOP [6]
References
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External links
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- Neuromedin U Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
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- ↑ Kajino M, Hinuma S, Tarui N, Yamashita T, Nakayama Y. Receptor regulators. European Patent EP 1559428 A1. Published 03.08.2005
- ↑ Lua error in package.lua at line 80: module 'strict' not found.