CDH4
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Cadherin-4 is a protein that in humans is encoded by the CDH4 gene.[1][2][3]
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.[3]
Interactions
Cadherin-4 has been shown to interact with:
References
Further reading
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External links
- CDH4 human gene location in the UCSC Genome Browser.
- CDH4 human gene details in the UCSC Genome Browser.
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