EIF-2 kinase
From Infogalactic: the planetary knowledge core
Regulation of translation initiation via phosphorylation of Ser51 in eIF2's α-subunit.[1]
eIF-2 is a kinase enzyme that phosphorylates eIF-2.[2]
There are four forms in mammals:
- EIF2AK1: heme-regulated inhibitor kinase (HRI)
- EIF2AK2: the double-stranded RNA-dependent kinase (PKR)
- EIF2AK3: PEK/PERK
- EIF2AK4: GCN2
These are all responsible for the phosphorylation of the alpha subunit of eIF-2 at serine 51, one of the best-characterized mechanisms for down-regulating protein synthesis in eukaryotes in response to various cellular stress response's.
References
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- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ eIF-2 Kinase at the US National Library of Medicine Medical Subject Headings (MeSH)
