HYDIA

HYDIA

Systematic (IUPAC) name
(1S,2R,3R,5R,6S)-2-amino-3-hydroxybicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Identifiers
PubChem	CID: 9794223
ChemSpider	7969990 N
Chemical data
Formula	C8H11NO5
Molecular mass	201.176 g/mol
SMILES C1[C@H]2[C@@H]([C@H]2[C@@]([C@@H]1O)(C(=O)O)N)C(=O)O
InChI InChI=1S/C8H11NO5/c9-8(7(13)14)3(10)1-2-4(5(2)8)6(11)12/h2-5,10H,1,9H2,(H,11,12)(H,13,14)/t2-,3+,4-,5-,8-/m0/s1 N Key:NTPXNEQCDPWJQA-AZDHXYLBSA-N N
NY (what is this?)  (verify)

HYDIA is a drug that is used in neuroscience research, which acts as a potent and selective antagonist for the group II metabotropic glutamate receptors (mGluR_2/3). It has been useful in the mapping of the group II mGluR receptor proteins and their molecular modeling. HYDIA is similar in structure to group II mGluR agonists such as eglumegad and LY-404,039, but the addition of the 3-hydroxy group reverses the activity to a competitive antagonist. Other derivatives such as the 3-benzyloxy ether are more potent antagonists than HYDIA itself.