Talampanel

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Talampanel
Talampanel skeletal.svg
Systematic (IUPAC) name
(8R)-7-Acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h] [2,3]benzodiazepine
Clinical data
Legal status
  • Investigational
Identifiers
CAS Number 161832-65-1 N
ATC code none
PubChem CID: 164509
ChemSpider 144217 N
UNII CVS43XG1L5 YesY
ChEMBL CHEMBL61872 N
Chemical data
Formula C19H19N3O3
Molecular mass 337.372 g/mol
  • Nc4ccc(cc4)C(=NN2C(=O)C)c3cc1OCOc1cc3CC2C
  • InChI=1S/C19H19N3O3/c1-11-7-14-8-17-18(25-10-24-17)9-16(14)19(21-22(11)12(2)23)13-3-5-15(20)6-4-13/h3-6,8-9,11H,7,10,20H2,1-2H3/t11-/m1/s1 N
  • Key:JACAAXNEHGBPOQ-LLVKDONJSA-N N
 NYesY (what is this?)  (verify)

Talampanel (INN) (code names GYKI 537773, LY300164) is a drug which has been investigated for the treatment of epilepsy,[1][2] malignant gliomas[3] and amyotrophic lateral sclerosis (ALS).[4]

As of May 2010, results from the trial for ALS have been found negative.[5] Talampanel is not currently under development.

Talampanel acts as a non-competitive antagonist of the AMPA receptor, a type of glutamate receptor in the central nervous system.[6]

See also

References

  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  5. ↑ Talampanel Trial, Talampanel Trial on alsa.org
  6. ↑ Lua error in package.lua at line 80: module 'strict' not found.


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