KCNC2

Potassium channel, voltage gated Shaw related subfamily C, member 2
Identifiers
Symbols	KCNC2 ; KV3.2
External IDs	OMIM: 176256 MGI: 96668 HomoloGene: 71199 IUPHAR: 549 GeneCards: KCNC2 Gene
Gene ontology Molecular function • voltage-gated potassium channel activity • delayed rectifier potassium channel activity • ion channel binding Cellular component • intracellular • plasma membrane • integral component of plasma membrane • voltage-gated potassium channel complex • membrane • integral component of membrane • basolateral plasma membrane • apical plasma membrane • cell junction • axon • dendrite • axolemma • vesicle • neuronal cell body membrane • presynaptic membrane • terminal bouton • perikaryon • synapse • postsynaptic membrane Biological process • action potential • energy reserve metabolic process • synaptic transmission • response to light intensity • response to organic cyclic compound • response to amine • globus pallidus development • response to magnesium ion • nitric oxide-cGMP-mediated signaling pathway • small molecule metabolic process • response to ethanol • regulation of insulin secretion • protein homooligomerization • protein heterooligomerization • cellular response to ammonium ion • cellular response to nitric oxide • potassium ion transmembrane transport • cellular response to toxic substance • positive regulation of potassium ion transmembrane transport • response to nerve growth factor Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3747	268345
Ensembl	ENSG00000166006	ENSMUSG00000035681
UniProt	Q96PR1	Q14B80
RefSeq (mRNA)	NM_001260497	NM_001025581
RefSeq (protein)	NP_001247426	NP_001020752
Location (UCSC)	Chr 12: 75.04 – 75.21 Mb	Chr 10: 112.27 – 112.47 Mb
PubMed search	[1]	[2]

Potassium voltage-gated channel subfamily C member 2 is a protein that in humans is encoded by the KCNC2 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit (Kv3.2).

Expression pattern

K_v3.1 and K_v3.2 channels are prominently expressed in neurons that fire at high frequency. K_v3.2 channels are prominently expressed in brain (fast-spiking GABAergic interneurons of the neocortex, hippocampus, and caudate nucleus; terminal fields of thalamocortical projections), and in retinal ganglion cells.

Physiological role

K_v3.1/K_v3.2 conductance is necessary and kinetically optimized for high-frequency action potential generation. Sometimes in heteromeric complexes with K_v3.1; important for the high-frequency firing of fast spiking GABAergic interneurons and retinal ganglion cells; and GABA release via regulation of action potential duration in presynaptic terminals.

Pharmacological properties

K_v3.2 currents in heterologous systems are highly sensitive to external tetraethylammonium (TEA) or 4-aminopyridine (4-AP) (IC₅₀ values are 0.1 mM for both of the drugs). This can be useful in identifying native channels.

Transcript variants

There are four transcript variants of K_v3.2 gene: K_v3.2a, K_v3.2b, K_v3.2c, K_v3.2d. K_v3.2 isoforms differ only in their C-terminal sequence.

External links

• Kv3.2 Potassium Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
• KCNC2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)