TPCN1

Two pore segment channel 1
Identifiers
Symbols	TPCN1 ; TPC1
External IDs	OMIM: 609666 MGI: 2182472 HomoloGene: 9905 IUPHAR: 392 GeneCards: TPCN1 Gene
Gene ontology Molecular function • voltage-gated calcium channel activity • protein binding • identical protein binding • NAADP-sensitive calcium-release channel activity Cellular component • lysosomal membrane • plasma membrane • endosome membrane • integral component of membrane Biological process • calcium ion transport • ion transmembrane transport • regulation of ion transmembrane transport • transmembrane transport • calcium ion transmembrane transport • membrane depolarization during action potential Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	53373	252972
Ensembl	ENSG00000186815	ENSMUSG00000032741
UniProt	Q9ULQ1	Q9EQJ0
RefSeq (mRNA)	NM_001143819	NM_145853
RefSeq (protein)	NP_001137291	NP_665852
Location (UCSC)	Chr 12: 113.22 – 113.3 Mb	Chr 5: 120.53 – 120.59 Mb
PubMed search	[1]	[2]

Two pore segment channel 1 (TPC1) is a human protein encoded by the TPCN1 gene. The protein encoded by this gene is an ion channel. In contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments (S1 to S6), TPCN1 only contains two domains (each containing segments S1 to S6).

See also

• Two-pore channel

External links

• TPCN1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)