Phospholipase D1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Phospholipase D1 is an enzyme that in humans is encoded by the PLD1 gene.[1][2]
Function
Phosphatidylcholine (PC)-specific phospholipases D (PLDs) EC 3.1.4.4 catalyze the hydrolysis of PC to produce phosphatidic acid and choline. A range of agonists acting through G protein-coupled receptors and receptor tyrosine kinases stimulate this hydrolysis. PC-specific PLD activity has been implicated in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis (Hammond et al., 1995).[supplied by OMIM][3]
Interactions
Phospholipase D1 has been shown to interact with:
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Inhibitors
- VU-0359595: 1,700-fold selective versus phospholipase D2, IC50 = 3.7nM.[13]
References
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