Tromantadine

Tromantadine

Skeletal formula
Ball-and-stick model
Systematic (IUPAC) name
N-1-adamantyl-N-[2-(dimethylamino)ethoxy]acetamide
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Topical
Identifiers
CAS Number	53783-83-8 N
ATC code	D06BB02 (WHO) J05AC03
PubChem	CID: 64377
ChemSpider	57947 Y
UNII	H191JFG8WA Y
KEGG	D07199 Y
NIAID ChemDB	007760
Chemical data
Formula	C16H28N2O2
Molecular mass	280.406 g/mol
SMILES O=C(NC13CC2CC(CC(C1)C2)C3)COCCN(C)C
InChI InChI=1S/C16H28N2O2/c1-18(2)3-4-20-11-15(19)17-16-8-12-5-13(9-16)7-14(6-12)10-16/h12-14H,3-11H2,1-2H3,(H,17,19) Y Key:UXQDWARBDDDTKG-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Tromantadine is an antiviral medicine used to treat herpes simplex virus. It is available in a topical gel under trade name Viru-Merz. Its performance is similar to aciclovir.

Like rimantadine, amantadine, and adapromine, tromantadine is a derivative of adamantane.

Mechanism

Tromantadine inhibits the early and late events in the virus replication cycle. It changes the glycoproteins of the host cells, therefore impeding the absorption of the virus. It inhibits penetration of the virus. It also prevents uncoating of the virions.

External links

• Viru-Merz website