CXCL9

Chemokine (C-X-C motif) ligand 9
Identifiers
Symbols	CXCL9 ; CMK; Humig; MIG; SCYB9; crg-10
External IDs	OMIM: 601704 MGI: 1352449 HomoloGene: 1813 GeneCards: CXCL9 Gene
Gene ontology Molecular function • cytokine activity • protein binding • chemokine activity • CXCR3 chemokine receptor binding Cellular component • extracellular region • extracellular space • external side of plasma membrane Biological process • positive regulation of leukocyte chemotaxis • chemotaxis • defense response • inflammatory response • immune response • cellular defense response • signal transduction • G-protein coupled receptor signaling pathway • cell-cell signaling • T cell chemotaxis • positive regulation of cAMP metabolic process • response to lipopolysaccharide • regulation of cell proliferation • positive regulation of cAMP-mediated signaling • positive regulation of myoblast differentiation • positive regulation of release of sequestered calcium ion into cytosol • defense response to virus • chemokine-mediated signaling pathway • positive regulation of myoblast fusion Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE CXCL9 203915 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4283	17329
Ensembl	ENSG00000138755	ENSMUSG00000029417
UniProt	Q07325	P18340
RefSeq (mRNA)	NM_002416	NM_008599
RefSeq (protein)	NP_002407	NP_032625
Location (UCSC)	Chr 4: 76 – 76.01 Mb	Chr 5: 92.32 – 92.33 Mb
PubMed search	[1]	[2]

Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family that is also known as Monokine induced by gamma interferon (MIG). CXCL9 is a T-cell chemoattractant, which is induced by IFN-γ. It is closely related to two other CXC chemokines called CXCL10 and CXCL11, whose genes are located near the gene for CXCL9 on human chromosome 4. CXCL9, CXCL10 and CXCL11 all elicit their chemotactic functions by interacting with the chemokine receptor CXCR3.

Neutrophil collagenase/matrix metalloproteinase 8 (MMP-8) degrades CXCL9 and cleaves CXCL10 at two positions.

Gelatinase B/matrix metalloproteinase 9 (MMP-9) degrades CXCL10 and cleaves CXCL9 at three different sites in its extended carboxy-terminal region.

Interactions

CXCL9 has been shown to interact with CXCR3.