Lipopeptide
| Cyclic lipopeptide antibiotics | |
|---|---|
| Identifiers | |
| Symbol | N/A |
| TCDB | 1.D.15 |
| OPM superfamily | 172 |
| OPM protein | 1t5n |
A lipopeptide is a molecule consisting of a lipid connected to a peptide. Bacteria express these molecules. They are bound by TLR 2, which form an eterodimer with TLR6 or TLR1.
Certain lipopeptides are used as antibiotics.[1][2] Certain lipopeptides could have strong anifungtal and hemolytic activities.[3] It has been demonstrated that their activity is generally linked to interactions with the plasma membrane [4] and sterol components of plasma membrane could play a major role and can be their privileged partner of interaction.[5][6]
Examples
See also
References
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- ↑ US Patent 6911525 - Lipopeptides as antibacterial agents
- ↑ Daptomycin: a lipopeptide antibiotic for the treatment of serious Gram-positive infections , Judith N. Steenbergen*, Jeff Alder, Grace M. Thorne and Francis P. Tally , Journal of Antimicrobial Chemotherapy 2005 55(3):283-288; doi:10.1093/jac/dkh546
- ↑ Maget-Dana, R., & Peypoux, F. (1994). Iturins, a special class of pore-forming lipopeptides: biological and physicochemical properties. Toxicology, 87(1-3), 151–74
- ↑ Nasir, M. N., Besson, F., & Deleu, M. (2013). Interactions des antibiotiques ituriniques avec la membrane plasmique. Apport des systèmes biomimétiques des membranes. Biotechnology, Agronomy and Society and Environment, 17(3), 505–516.
- ↑ Nasir, M. N., & Besson, F. (2012). Interactions of the antifungal mycosubtilin with ergosterol-containing interfacial monolayers. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1818(5), 1302–1308
- ↑ Nasir, M. N., & Besson, F. F. (2011). Specific Interactions of Mycosubtilin with Cholesterol-Containing Artificial Membranes. Langmuir : The ACS Journal of Surfaces and Colloids, 27(17), 10785–10792.
